Research

Membrane determinants for lipid droplet protein binding 

Screen Shot 2014-03-22 at 12.16.15 PM

Thiam et al. 2013 Nat.Rev.Mol.Cell.Bio

screen-shot-2017-02-14-at-14-19-49

Thiam et al. 2017 JCS

We are interested in the regulation of protein binding to lipid droplets.

We use reconstitution assays to probe the interaction of purified proteins with model membranes made with emulsion droplets and liposomes.

We probe in cells the how the determined parameters affect protein localization.

                                    

 

 

 

Biophysical regulation of neutral lipids accumulation 

We are interested in the impact of surfactant lipids and membrane physical properties on the fate of lipid droplets, from their formation to utilization.

screen-shot-2017-02-14-at-14-18-49 screen-shot-2017-02-14-at-14-18-40

Thiam et al. 2016 Mol. and Cell Bio. of lipids

Droplet interface bilayers with Microfluidics

Screen Shot 2014-03-22 at 12.11.12 PMWe develop droplet microfluidics to generate high throughput model bilayers for detecting protein activity/functionality.

demarrang